Original Investigation

Outcomes of Moderate-to-Severe Traumatic Brain Injury in a Low-Resource Setting

JAMA Network Open 10.1001/jamanetworkopen.2026.28403

August 11, 2026 at 11:00 AM EDT

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In this cohort study of patients in Pakistan with msTBI, mortality was high, particularly among those with severe TBI, and most posthospital deaths occurred within the first month after hospital discharge. Older age, no surgical intervention, and greater injury severity were associated with higher mortality, highlighting the need for improved acute and postdischarge care in resource-limited settings.

Corresponding Author: Kantesh Kumar, MBBS, Centre of Excellence for Trauma and Emergencies, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan (kantesh.kumar23@alumni.aku.edu).

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