Original Investigation

Diet Quality and Dementia Risk in Older Adults With Alzheimer Pathology

JAMA Network Open 10.1001/jamanetworkopen.2026.20254

June 25, 2026 at 11:00 AM EDT

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Is higher diet quality associated with lower dementia risk among older adults with Alzheimer disease pathology or broader neurodegenerative and glial processes?In this cohort study of 1865 older adults without dementia followed up for up to 15 years, higher diet quality was associated with lower dementia risk. Among participants at higher risk, only a dietary pattern with lower inflammatory potential showed consistent inverse associations.These findings reinforce the importance of targeted dietary dementia prevention strategies for the general population and individuals already at elevated risk.

Corresponding Author: Anja Mrhar, MSc, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva ulica 101, 1000 Ljubljana, Slovenia (anja.mrhar@ki.se).

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