Original Investigation

Japanese Encephalitis Vaccine Decision Aid for Travelers

JAMA Network Open 10.1001/jamanetworkopen.2026.15190

June 01, 2026 at 11:00 AM EDT

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Can a web-based Japanese encephalitis (JE) vaccine decision aid improve decision-making and vaccine uptake among Australian travelers compared with an online government JE information resource?In this randomized clinical trial of 814 adults planning travel to JE-endemic countries, both resources significantly reduced decisional conflict, with no between-group difference. Among the 348 travelers completing follow-up, vaccine uptake was significantly higher in the intervention group (43% vs 28%).Decision aids may support informed, values-congruent choices in complex, preference-sensitive health decisions such as travel vaccination, complementing clinician advice.

Corresponding Author: Sarah L. McGuinness, MBBS, MPHTM, PhD, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne VIC 3004, Australia (sarah.mcguinness@monash.edu).

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