Digital Microsteps as Scalable Adjuncts for Adults Using GLP-1 Receptor Agonists

Among adults using glucagon-like peptide-1 receptor agonists (GLP-1 RAs), can a brief digital intervention, consisting of written behavior change prompts accompanied by short videos, boost expectations to adopt health lifestyle behaviors?In this randomized clinical trial of 5054 global adults using GLP-1 RAs, single exposure to behavior change prompts with either storytelling or didactic video boosters significantly improved behavioral expectation to adopt health behaviors immediately after exposure, with effects still evident 2 weeks later. The storytelling video showed stronger effects across most domains.The findings of this study demonstrate that even a single, low-cost digital exposure can measurably boost expectations to adopt health lifestyle behaviors in adults using GLP-1 RAs, suggesting that scalable digital microinterventions could complement pharmacotherapy and warrant testing in longer trials.

Corresponding Author: Maya Adam, MD, PhD, Department of Pediatrics, Stanford University School of Medicine, 291 Campus Dr, Stanford, California 94305 (madam@stanford.edu).

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