Early Prophylactic Hydrocortisone and Bronchopulmonary Dysplasia–Free Survival in Extremely Preterm Infants

After guideline implementation, has early prophylactic hydrocortisone improved survival without bronchopulmonary dysplasia (BPD) in extremely preterm infants born in Sweden, and is it safe to use?In this cohort study using prospectively collected data from 1106 infants from a national register, introduction of prophylactic hydrocortisone was followed by an increased likelihood of survival without BPD. There was no significant increase in severe neonatal morbidities.These findings, based on clinical implementation data, suggest alignment with previous similar studies supporting the benefits and safety of early prophylactic hydrocortisone treatment.

Corresponding Author: Veronica Smedbäck, MS in Medicine, PhD-student, Department of Biomedical and Clinical Sciences, Division of Children’s and Women’s Health, Linköping University, Campus US, 581 85 Linköping, Sweden (veronica.smedback@liu.se).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.