Human Milk and Infant Gut Microbiome in Association With Infant Fecal Metabolome and Child Blood Pressure

Does human milk feeding interact with infant gut microbes, particularly subsp and other milk-degrading microbes, in association with infant fecal metabolome and childhood blood pressure?In this cohort study of 1324 Canadian children, any human milk feeding, compared with no human milk feeding, at age 3 months was associated with lower child systolic blood pressure at ages 3 and 5 years among infants harboring at age 3 months, but not among infants who did not harbor . An interaction was also observed between human milk feeding and several other microbes at age 3 months (but not age 12 months), including other species of , in relation to child blood pressure and fecal metabolites.These findings suggest that early-life interactions between human milk feeding and infant gut microbes may shape the infant fecal metabolome and child blood pressure.

Corresponding Author: Noel T. Mueller, PhD, MPH, Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, 1890 N Revere Ct, Anschutz Health Sciences Bldg, 1st Floor, Ste 1002, Mail Stop F426, Aurora, CO 80045 (noel.mueller@cuanschutz.edu).

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