Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries

Are blood-based tau biomarkers clinically useful to monitor neurological injuries in patients with multiple traumatic injuries?In this cohort study with 69 participants, total, phosphorylated, and brain-derived tau blood levels were significantly elevated in patients with multiple traumatic injuries, with and without head injury. Tau concentrations were associated with injury severity, shock, and clinical outcome.These findings suggest that further research may inform on the usefulness of blood-based tau biomarkers for monitoring neurological damage and their association with clinical outcomes.

Corresponding Authors: Fernando Gonzalez-Ortiz, MD, PhD, Department of Psychiatry and Neurochemistry, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, SE-43180 Mölndal, Sweden (fernando.gonzalez.ortiz@gu.se); Rebecca Halbgebauer, MD, PhD, Institute of Clinical and Experimental Trauma Immunology, Ulm University Medical Center, D-89081 Ulm, Germany (rebecca.halbgebauer@uniklinik-ulm.de).

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