A Geographically Sensitive Neighborhood Exposome–Wide Association Study for Breast Cancer Survival

Can a novel analytic framework uncover more information regarding the neighborhood exposome’s association with breast cancer survival?This cohort study of 2727 women diagnosed with breast cancer in Virginia developed a geographically sensitive neighborhood exposome–wide association study analytic framework to identify which specific neighborhood exposome indicators are relevant for cancer outcomes and determine the geographic scale of their operation. Four components, including housing cost and density, recent relocation, and the number of children enrolled in public preschools, were associated with shorter survival.This framework provides precise insights on how the neighborhood exposome was associated with health outcomes, in particular financial and housing-related stress for breast cancer survival.

Corresponding Author: Joseph Boyle, PhD, Department of Family Medicine and Population Health, Virginia Commonwealth University, 830 E Main St, Richmond, VA 23219 (boylejr@vcu.edu).

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