Platelet Transfusion Practices and Outcomes in Neonates and Children

What is the epidemiology of platelet transfusions in pediatric and neonatal recipients, and are donor and platelet processing factors associated with posttransfusion platelet increments, overall transfusion burden, and clinical outcomes?In this cohort study involving 249 340 inpatient encounters, 3.6% of patients received platelet transfusions. Lower platelet increments and a higher transfusion burden were observed for the use of platelet additive solution, pathogen reduction, and platelets with longer storage durations, and there was a similar association with donor age; whereas these donor and platelet factors were not associated with adverse clinical outcomes.This study describes platelet transfusion practices in neonates and children and various platelet processing and donor characteristics associated with posttransfusion platelet increments and overall transfusion burden.

Corresponding Author: Ruchika Goel, MD, MPH, CABP, Division of Hematology/Oncology, Simmons Cancer Institute at SIU School of Medicine, Southern Illinois University School of Medicine, 315 W Carpenter St, Springfield, IL 62702 (rgoel71@siumed.edu).

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