Racial, Ethnic, and Socioeconomic Survival Disparities in Early-Onset Metastatic Colorectal Cancer
JAMA Network Open 10.1001/jamanetworkopen.2025.53146January 08, 2026 at 11:00 AM EST
Are race and ethnicity and neighborhood-level socioeconomic status (SES) associated with mortality among young adults with metastatic colorectal cancer (mCRC)?In this cohort study of 3115 young adults with mCRC, 3-year survival was lower among Black patients (40.7%) and patients in the lowest SES quintile (40.6%). Patients living in the lowest SES quintile had 51% higher risk of mortality, and Black patients had 8% higher risk of mortality, although the latter association was not statistically significant after adjusting for sociodemographic, tumor, and treatment characteristics.These findings suggest that structural conditions, such as neighborhood-level SES, impact survival among young adults with mCRC.
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