Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults

Are plasma biomarkers for Alzheimer disease associated with subjective cognitive decline (SCD) in Hispanic and/or Latino adults?In this cross-sectional study of 5712 Hispanic and/or Latino adults aged 50 to 86 years, higher phosphorylated tau-181, neurofilament light chain, and glial fibrillary acidic protein levels were associated with greater SCD, assessed with the Everyday Cognition Scale, but not cognitive concerns. No associations were found for amyloid-beta levels.These findings suggest that tau pathology, neurodegeneration, and neuroinflammation may reflect early cognitive changes and help identify at-risk individuals among Hispanic and/or Latino adults.

Corresponding Author: Freddie Márquez, PhD, Department of Neurosciences, UC San Diego, 9500 Gilman Dr, Ste 0949, La Jolla, CA 92093-0949 (frmarquez@ucsd.edu).

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