Original Investigation

Bariatric Surgery and Incident Development of Obesity-Related Comorbidities

JAMA Network Open 10.1001/jamanetworkopen.2025.30787

September 09, 2025 at 11:00 AM EDT

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In patients with obesity, does bariatric surgery reduce the risk of developing metabolic comorbidities compared with a medical weight management program?In this cohort study of 269 470 veterans, bariatric surgery was associated with a significantly lower risk of incident type 2 diabetes, hypertension, hyperlipidemia, obstructive sleep apnea, and metabolic dysfunction–associated steatotic liver disease, compared with the weight management program, over 5 years.Bariatric surgery may be a durable option for lowering the risk of developing metabolic comorbidities in patients with obesity.

Corresponding Author: Amanda L. Bader, MD, Hospital of the University of Pennsylvania, 3400 Spruce St, 4 Maloney Building, Philadelphia, PA 19104 (amanda.bader@pennmedicine.upenn.edu).

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