Low Measles Seropositivity in Vaccinated Children

What is the measles-specific antibody seroprevalence among vaccinated children in southern India?In this cross-sectional study of 684 children and their 544 mothers from the states of Kerala and Tamil Nadu, 90.8% of vaccinated children had positive measles-specific immunoglobulin G (IgG) and 91.5% had protective neutralizing antibody titers. The presence of measles-specific IgM in 13% of vaccinated children and the elevated neutralizing antibody titers in mothers suggest ongoing virus circulation within the community.These findings highlight immunity gaps in vaccinated children in India hindering measles elimination efforts, emphasizing the need to elucidate mechanisms driving suboptimal immune responses to measles vaccination.

Corresponding Author: Richard B. Kennedy, PhD, Mayo Clinic Vaccine Research Group, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (kennedy.rick@mayo.edu).

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