Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension

How are peripheral vasopressors used in early sepsis resuscitation, and is their use safe?In this cohort study of 582 patients from the Crystalloid Liberal vs Early Vasopressors in Sepsis trial, most patients had vasopressors initiated through peripheral venous catheters, and more than one-half had vasopressors continued through peripheral catheters beyond 6 hours. Complications of peripheral vasopressor administration were rare, and there was no association of vasopressor route with mortality, even after adjustment for patient characteristics.These findings suggest that early peripheral vasopressor use is a feasible and safe approach for managing sepsis-induced hypotension in appropriately monitored settings.

Corresponding Author: Elizabeth S. Munroe, MD, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, 1150 W Medical Center Dr, 6301 MSRB III, SPC 5642, Ann Arbor, MI 48109 (munroeel@med.umich.edu).

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