Dynamic Prognostic Models for Colorectal Cancer With Liver Metastases

Can longitudinal laboratory markers improve prediction models for progression-free and overall survival in patients with colorectal liver metastases (CRLM) after resection?In this prognostic study of 976 patients with CRLM, the dynamic prediction models incorporating multiple longitudinal markers consistently outperformed models based on static clinicopathologic and baseline laboratory data in predicting progression-free and overall survival, with improved areas under the receiver operating characteristic curve and Brier scores across multiple time points.These findings suggest that dynamic prediction models offer a practical approach to more precise and personalized risk assessment for patients with CRLM, potentially informing tailored clinical management.

Corresponding Authors: Hong Zhao, MD, Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing, China, 100021 (zhaohong@cicams.ac.cn); Kan Li, PhD, Merck kan.li@merck.com).

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