Poststroke Cardiorespiratory Exercise for Brain Volume and Cognition

Does cardiorespiratory exercise (CRX) preserve brain volume and cognition after stroke?In this randomized clinical trial of 104 patients who survived ischemic stroke, an 8-week CRX intervention delivered at 2 months post stroke was safe but did not preserve hippocampal volume more than the balance and stretching control. However, executive and global cognitive performance at 12 months post stroke was better in the CRX group.CRX delivered 2 months after stroke was safe; while it did not preserve hippocampal volume more than the control condition, there was promising evidence of preserved cognition at 12 months after stroke.

Corresponding Author: Amy Brodtmann, PhD, Neurosciences, Monash University Central Clinical School, 99 Commercial Rd, Level 6, The Alfred Centre, Melbourne, VIC 3004, Australia (amy.brodtmann@monash.edu).

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