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Steatotic Liver Disease Risk Scores to Predict Cirrhosis and Hepatocellular Carcinoma

JAMA Internal Medicine 10.1001/jamainternmed.2026.4110

September 21, 2026 at 11:00 AM EDT

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The findings of this cohort study show that the SAFE score may inform decisions to repeat screening for cirrhosis in patients with SLD. Clinical risk scores for HCC demonstrated minimal utility to inform HCC screening decisions for patients with noncirrhotic SLD.

Corresponding Author: Catherine Mezzacappa, MD, PhD, MPH, Section of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, 333 Cedar St, 1080 LMP, PO Box 208019, New Haven, CT 06520-8019 (catherine.mezzacappa@yale.edu).

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