Discordance in Treatment Response Assessment Between Clinicians and Patients With Skin Chronic Graft-vs-Host Disease

What are the prevalence and factors associated with discordance in clinician-reported and patient-reported treatment response of cutaneous chronic graft-vs-host disease (GVHD), and which response measures are associated with survival?In this cohort study including 489 adults with cutaneous chronic GVHD, discordance in treatment response between patients and clinicians was common, yet both measures were independently associated with survival. Patients with sclerosis were more likely to have discordance, and only patient-reported treatment response was associated with survival.Patient-reported outcome measures should be collected alongside clinician-reported outcome measures because they are often discordant and may be associated with survival, particularly in sclerotic disease.

Corresponding Author: Emily Baumrin, MD, MSCE, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Tower, Ste 729, Philadelphia, PA 19104 (emily.baumrin@pennmedicine.upenn.edu).

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