Original Investigation

Multidimensional Aging Trajectories Preceding Cardiovascular Events

JAMA Cardiology 10.1001/jamacardio.2026.3597

September 23, 2026 at 11:00 AM EDT

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Results of this nested case-control study show that declines in functional aging markers were prominent before clinically apparent CVD, suggesting that they may represent the culmination of progressive multisystem aging and indicating a prolonged window of opportunity for closer clinical evaluation and early intervention.

Corresponding Author: Aung Zaw Zaw Phyo, PhD, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC 3004, Australia (aungzawzaw.phyo@monash.edu).

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