Original Investigation

Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock

JAMA Cardiology 10.1001/jamacardio.2025.3337

August 30, 2025 at 5:00 AM EDT

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Does systolic blood pressure (SBP) modify the survival benefit of microaxial flow pump therapy in ST-segment elevation myocardial infarction–related cardiogenic shock?In this post hoc analysis of the DanGer Shock randomized clinical trial including 351 patients, SBP at randomization significantly modified the survival benefit of microaxial flow pump therapy, with benefit most pronounced in patients with the lowest SBPs. Adverse events occurred independently of SBP at randomization.Early SBP may help identify patients most likely to derive a net benefit from microaxial flow pump treatment in infarct-related cardiogenic shock.

Corresponding Author: Astrid Duus Mikkelsen, MD, Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark (astrid.duus.mikkelsen@reigonh.dk).

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