Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes

What are the associations of lifestyle and metformin interventions compared with placebo on the occurrence of multimorbidity in adults with prediabetes?In 1173 participants enrolled in Medicare and followed up for 21 years after enrolling in a randomized clinical trial, 82%, 85%, and 87% experienced multimorbidity among lifestyle, metformin, and placebo groups, respectively. The risk of multimorbidity was significantly lower in the group randomly assigned to lifestyle intervention compared with the placebo group after adjustment for relevant covariates, and there was no significant difference between the metformin and placebo groups.Among adults with prediabetes at baseline, lifestyle intervention, but not metformin, was associated with a lower risk of multimorbidity during 21 years of follow-up.

Corresponding Author: Marcel E. Salive, MD, DPPOS Coordinating Center, The George Washington University Biostatistics Center, 6710A Rockledge Dr, Ste 250, Bethesda, MD 20817 (dppmail@bsc.gwu.edu).

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