Original Investigation

Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion

JAMA 10.1001/jama.2026.15496

September 23, 2026 at 11:00 AM EDT

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Among patients with moderate to severe basilar artery occlusion admitted directly to EVT-capable centers who presented 4.5 to 24 hours after stroke onset, the addition of intravenous tenecteplase before EVT did not result in improved functional outcomes compared with EVT alone.

Corresponding Authors: Wei Hu, MD, PhD, Department of Neurology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Tianehu Road, Hefei 230001, Anhui, China (andinghu@ustc.edu.cn); Thanh N. Nguyen, MD, PhD, Department of Neurology thanh.nguyen@bmc.org).

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