RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons

What is the effectiveness of 1 dose of respiratory syncytial virus (RSV) vaccine against RSV-associated hospitalization among adults aged 60 years or older during 2 RSV seasons and by time since vaccination?In this multicenter, test-negative, case-control study of 6958 adults with RSV, estimated RSV vaccine effectiveness against RSV-associated hospitalization during 2 seasons was 58%. Vaccine effectiveness was 69% when vaccination occurred in the same season before illness onset and 48% when vaccination occurred in the prior season; these estimates were not statistically significantly different.One dose of RSV vaccine prevented RSV-associated hospitalization during 2 RSV seasons.

Corresponding Author: Diya Surie, MD, Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS H24-9, Atlanta, GA 30333 (dsurie@cdc.gov).

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